Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients

M Lõpez-Solà; J Pujol; TD Wager; A Garcia-Fontanals; L Blanco-Hinojo; S Garcia-Blanco; V Poca-Dias; BJ Harrison; O Contreras-Rodríguez; J Monfort; F Garcia-Fructuoso; J Deus

Journal article

Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients

M Lõpez-Solà, J Pujol, TD Wager, A Garcia-Fontanals, L Blanco-Hinojo, S Garcia-Blanco, V Poca-Dias, BJ Harrison, O Contreras-Rodríguez, J Monfort, F Garcia-Fructuoso, J Deus

Arthritis and Rheumatology | Published : 2014

DOI: 10.1002/art.38781

Abstract

Objective Fibromyalgia (FM) is a disorder characterized by chronic pain and enhanced responses to acute noxious events. However, the sensory systems affected in FM may extend beyond pain itself, as FM patients show reduced tolerance to non-nociceptive sensory stimulation. Characterizing the neural substrates of multisensory hypersensitivity in FM may thus provide important clues about the underlying pathophysiology of the disorder. The aim of this study was to characterize brain responses to non-nociceptive sensory stimulation in FM patients and their relationship to subjective sensory sensitivity and clinical pain severity. Methods Functional magnetic resonance imaging (MRI) was used to ass..

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University of Melbourne Researchers

Ben Harrison Author

Related Projects (1)

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Grants

Awarded by National Institute on Drug Abuse

Funding Acknowledgements

Supported in part by the Ministry of Science and Innovation of Spain (grant SAF2010-19434), the NIH (grant R01-DA-035484 to Dr. Wager), and the Agency of University and Research Funding Management of the Catalonia Government AGAUR (Research Groups SGR 2009/718, 1435, and 1450). Dr. Lopez-Sola's work was supported by a Beatriu de Pinos-A Postdoctoral Fellowship (2010_BP_A_00136) from the Government of Catalunya. Dr. Garcia-Fontanals' work was supported by a Personal Investigador en Formacion (PIF) grant from the Autonomous University of Barcelona. Ms Blanco-Hinojo's work was supported by the Predoctoral Training Grant Research Programme (PFIS grant FI10/00387) from the Carlos III Health Institute. Dr. Harrison's work was supported by the National Health and Medical Research Council of Australia (NHMRC Clinical Career Development award 628509).